Learning Resources

• Rogers, (2023). McCance & Huether’s pathophysiology (9th ed.). Elsevier – Evolve.
• Chapter 1: Cellular Biology: Summary Review
• Chapter 2: Altered Cellular and Tissue Biology: Environmental Agents:

Summary Review

• Chapter 3: The Cellular Environment: Fluids and Electrolytes, Acids and Bases: Summary Review
• Chapter 4: Genes and Genetic Diseases: Summary Review
• Chapter 5: Genes, Environment-Lifestyle, and Common Diseases: Summary Review
• Chapter 6: Epigenetics and Disease: 187195; pp. 198199.

A 34-year-old woman presents with 3 months of progressive fatigue and intermittent double vision. She reports that her eyelids droop by the end of the workday and improve after resting. She also notes:

• Difficulty chewing meat at dinner
• Slurred speech in the evenings
• Mild difficulty swallowing solid foods
• Increasing fatigue with prolonged talking

She denies numbness, tingling, muscle pain, or recent illness.

Physical Examination

• Vital signs stable
• Bilateral ptosis (worse with sustained upward gaze)
• Diplopia on lateral gaze
• Speech becomes nasal after prolonged conversation
• Motor strength 5/5 initially, decreases to 4/5 with repeated resistance testing
• Reflexes normal
• Sensation intact

Laboratory Data

Test

Result

CBC

Normal

CMP

Normal

TSH

2.1 IU/mL

ESR

10 mm/hr

ANA

Negative

Test

Result

Acetylcholine receptor antibodies

Elevated

Anti-MuSK antibodies

Negative

Repetitive nerve stimulation shows a decremental response. Chest CT reveals thymic hyperplasia.

Questions:

• Which genetic mutations are commonly associated with the disease?
• Why is the patient presenting with the specific symptoms described?
• Discuss the pathophysiological mechanisms of the disease in

What do the blood test results tell us about the disease and disease progression?

Learning Resources

• Rogers, (2023). McCance & Huether’s pathophysiology (9th ed.). Elsevier – Evolve.
• Chapter 1: Cellular Biology: Summary Review
• Chapter 2: Altered Cellular and Tissue Biology: Environmental Agents:

Summary Review

• Chapter 3: The Cellular Environment: Fluids and Electrolytes, Acids and Bases: Summary Review
• Chapter 4: Genes and Genetic Diseases: Summary Review
• Chapter 5: Genes, Environment-Lifestyle, and Common Diseases: Summary Review
• Chapter 6: Epigenetics and Disease: 187195; pp. 198199.

A 34-year-old woman presents with 3 months of progressive fatigue and intermittent double vision. She reports that her eyelids droop by the end of the workday and improve after resting. She also notes:

• Difficulty chewing meat at dinner
• Slurred speech in the evenings
• Mild difficulty swallowing solid foods
• Increasing fatigue with prolonged talking

She denies numbness, tingling, muscle pain, or recent illness.

Physical Examination

• Vital signs stable
• Bilateral ptosis (worse with sustained upward gaze)
• Diplopia on lateral gaze
• Speech becomes nasal after prolonged conversation
• Motor strength 5/5 initially, decreases to 4/5 with repeated resistance testing
• Reflexes normal
• Sensation intact

Laboratory Data

Test

Result

CBC

Normal

CMP

Normal

TSH

2.1 IU/mL

ESR

10 mm/hr

ANA

Negative

Test

Result

Acetylcholine receptor antibodies

Elevated

Anti-MuSK antibodies

Negative

Repetitive nerve stimulation shows a decremental response. Chest CT reveals thymic hyperplasia.

Questions:

• Which genetic mutations are commonly associated with the disease?
• Why is the patient presenting with the specific symptoms described?
• Discuss the pathophysiological mechanisms of the disease in

What do the blood test results tell us about the disease and disease progression?

I need a brain map and neurocircuitry in mental health disorders completed. Assignment would have to be completed using Canva. I have attached all instructions below. Please read all instructions thoroughly.

Post an explanation of the disease highlighted in the scenario you were provided. Include the following in your explanation:

• Which genetic mutations are commonly associated with the disease?
• Why is the patient presenting with the specific symptoms described?
• Discuss the pathophysiological mechanisms of the disease in detail.
• What do the blood test results tell us about the disease and disease progression?

References

Heijerman, H. G. M., McKone, E. F., Downey, D. G., Van Braeckel, E., Rowe, S. M., Tullis, E., … VX17-445-103 Trial Group. (2019). Efficacy and safety of the elexacaftor plus tezacaftor plus ivacaftor combination regimen in people with cystic fibrosis homozygous for the F508del mutation: A double-blind, randomised, phase 3 trial. The Lancet, 394(10212), 19401948.

Middleton, P. G., Mall, M. A., Devnek, P., Lands, L. C., McKone, E. F., Polineni, D., … VX17-445-102 Study Group. (2019). Elexacaftortezacaftorivacaftor for cystic fibrosis with a single Phe508del allele. The New England Journal of Medicine, 381(19), 18091819.

Rogers, J. (2023). McCance & Huethers pathophysiology: The biologic basis for disease in adults and children (9th ed.). Elsevier.

You pick your own pathology…..you create your own imaginary patient and answer all the questions from the table… 2. You will have a allowance of 30% of similarities….more than 3 points plus deducted…until 49%..you reach….50%…or more in use of Al or plagiarism is Zero…….(that includes combining both…for example 25% Al…..25%…plagiarism….equal to 50%…that is zero…. 3. If you deliver your case…before the end of that week… Friday of week 6)…. will allow to resubmit…JUST ONCE..to fix any potential problems with Al or plagiarism…if problems continues after that allowance…points will,….be deducted..I will not read same work more than twice……f you wait until Sunday to discover issues with Al….is Zero….Rules are clear…! don’t suppose to allow resubmit a work 4. Again…..DO NOT USE AI OR ANY APP TO CHECK GRAMMAR ERRORS…That will trigger red flags….same with Citation.. don’t make citations is a form of plagiarism If we follow those 4 rules…using your own wording in the old ways….you don’t suppose to have problems …..

Working with the attached file, write an integrated evidence- based comparism into practice decisions

AI predictions are compared thoroughly with the current literature

discuss the pathogenies of Parkinsons Disease please include references from evidence based and peer reviewed within the last 4 years also use book supplied as one of the references

Purpose

This assignment is intended to help you learn to analyze and explain the impact of infection, stress, and disease, and the associated pathological phenomena and details compared to normal physiology.

Overview

There are numerous articles, posts, podcasts, etc. on how to eliminate toxins from the body or how to cleanse the body of toxins. The digestive system is most often the target of the whole cleansing process. How can one separate fact from fiction?

Action Items

1. View the following video:
3. Respond to the following in your initial post: Is the information in the video supported by peer-reviewed research? Explain. You may choose to address the video as a whole, or choose one of the herbs presented in the video. Give your rationale and substantiate it with references, including your textbook and a minimum of 3 other credible, scholarly sources.

ment is to provide the learner with an opportunity to explore the physiologic and pathophysiologic genetic, epigenetic, and genomic factors that are related to the development of common disease processes. Please choose one of the following topics: Diabetes Mellitus (Type 2) The paper should be a minimum of 4 and a maximum of 5 pages (of content), excluding the title and reference page. Before beginning your paper, please go to the choice poll and select a disease process that you will focus on for your paper. Your paper must be submitted to Turnitin. Provide a physiologic overview of normal DNA function with a general definition of the alterations related to genetic, epigenetic, or genomic disorders (the definition should relate to the disease process that you have chosen for your paper topic) Describe the pathophysiology of your chosen disorder and identify DNA/cell alterations in the chosen disease process. Discuss the signs and symptoms of the disease process and the pathophysiology causing these signs and symptoms. Describe the diagnostic studies for the disease process. Discuss the expected findings from the diagnostic studies. For example, a person has chest pain. What is the pathophysiology that causes chest pain? Identify current treatment/management approaches to the selected disorder. References must include a minimum of four sources, with two of the sources being scholarly journals from the SUNY library meeting the criteria for being less than 5 years old.

Each student must post, at minimum, one substantial thread (1-2 paragraphs) and two follow-up threads (several sentences). Of course you may participate as much as you wish. To post the one substantial thread, which answers the discussion questions, click on “Reply” which directly follows the questions. To post a reply to another student, click on “Reply” at the bottom of that student’s post. Also, be sure to post early in the unit, as this leads to more vigorous and interactive discussion. Failure to post during the first week of the Module will result in a 25 point loss. If all posts are made within the last 3 days of the Module, 50 points will be deducted. Posting only once or twice will result in a 75 point loss. Failure to make any posts receives a zero. I do want discussion and not just a series of unrelated postings, so please respond to each other in meaningful ways. Factual information within posts must be referenced using APA format. The required text and lecture notes should be your primary source of information for referencing. You may also use valid online sources as references, however, if the information from these alternate sources conflicts with course material, points will be lost. Course material is the final authoritative source. Additionally, each reference must be specific so that the source of the information may be reviewed. If a general reference is provided, points will be deducted. It is strongly suggested that you review the Discussion Grading Rubric prior to participating in discussions. The rubric may be found in the MY Grades link, on the left side of the screen, under the heading for each Module. As a reminder, you should also review the Assignment Rubrics, which are found on the Assignment submission page, prior to submitting assignments. Please address the 2 questions following the Case Study for discussion: CASE STUDY A routine mammogram showed a large mass in the right breast of Mrs. H., age 42. A biopsy confirmed the presence of a malignant tumor. Mrs. H. was concerned because her mother and an aunt had breast cancer. No metastases were detected at this time. A mastectomy was performed and a number of axillary and mediastinal lymph nodes were removed. Pathologic examination showed several nodes from each area contained malignant cells. Given this case was considered to be stage III, it was recommended that Mrs. H. have chemotherapy and radiation treatment following surgery and later have her ovaries removed to reduce her estrogen levels. Discussion Questions Other than the biopsy used in this case, discuss what other diagnostic tests could have been used to diagnose the cancer. Discuss the reasons why the axillary lymph nodes were removed and it was recommended that the patient continue with prognosis.